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In individuals who are deficient or those under high physical stress, such as athletes, the benefits can be even more pronounced

Diabetes Care 42(7):1326-32 2019 PMC6609965 Temple KA, Tjaden AH, Atkinson KM, Barengolts E, Hannon TS, Mather KJ, Utzschneider KM, Edelstein SL, Ehrmann DA, Mokhlesi B, RISE Consortium
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[DOI] [PubMed] [Google Scholar] 359.Tesfaye, S

Of interest, the down-expression of ACC2 results from an epigenetic process linked to histone deacetylation at the ACACB promoter by Sirtuin 1/6 that are activated by high cytosolic NAD + levels associated with enhanced FAO and reduced glucose metabolism

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