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Although the safety of metformin use in early pregnancy has been tentatively affirmed, additional data are required to definitively confirm its safety profile

doi: 10.1038/nature13297 152 LohMZhangWNgHKSchmidKLamriATongLet al

Am J Physiol Renal Physiol 2011;301:F1334F1345

Experimental evidence supports that PA and its precursor, dexpanthenol, exhibit protective properties across various tissues due to their anti-inflammatory, antioxidant, and anti-apoptotic effects 21,22,23

The synergy claim is mechanistic, derived from the three peptides acting on different nodes of overlapping pathways (VEGF, NF-kB, ECM remodeling)

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