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Recently, the dramatic development of artificial intelligence (Al) meets the high demands of mining and translating the huge amount of datasets, which entails streamlining the vast volumes of imaging and molecular testing into clinically actionable knowledge data, especially important for reproductive physicians in assisting the management of patients [8, 9]

[Online] 128 QiuH.SunY.WangX.GongT.SuJ.ShenJ.et al (2024)

[77] compared the metabolic profile of CD patients intestinal mucosa (relative to the disease controls), blood plasma, and urine (relative to the healthy controls) samples using NMR spectroscopy and multivariate analysis and observed the changes in Pro, arginine (Arg), glycine (Gly), histidine (His), glutamate (Glu), aspartate (Asp), tryptophan (Trp), fumarate, formate, succinate (Succ), glycerophosphocholine (GPC) and allantoin (Alln) in the small intestinal mucosa and changes in Pro, Arg, Gly, alanine, Glu, Gln, glucose (Glc), lactate (Lac), acetate (Ace), acetoacetate (AcAc), -hydroxybutyrate (-OHB), pyruvate (Pyr), Succ, citrate (Cit), choline (Cho), creatine (Cr), phosphocreatine (PCr) and creatinine in blood plasma and changes in Pro, Trp, -OHB, Pyr, Succ, N-methylnicotinamide (NMN), aminohippurate (AHA), indoxyl sulfate (IS), and Alln in urine samples of CD patients [77]

Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injury