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2.3 Activation of endoplasmic reticulum stress Endoplasmic reticulum (ER) is a critical organelle for protein synthesis and maturation

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Further evidence that the production of TMAO is dependent on metabolism by intestinal microbiota is provided by studies in healthy humans given phosphatidylcholine challenge, in which the plasma levels of TMAO were suppressed by oral administration of broad spectrum antibiotics [14]