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Description
Oxalate crystals can accumulate in the joints, skin, vasculature, and even the brain leading to inflammation, mitochondrial dysfunction, and cell damage
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Endoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets like vascular endothelial growth factor (VEGF)
Alana Biggers, MD, MPH
