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Insulin-degrading enzyme, IDE

The transcriptional signatures identified in GLP-1MK-801-treated animals were enriched for functional terms related to synaptic transmission, such as postsynaptic density and glutamatergic synapse (Fig

This is the application area with the deepest preclinical history, and it is also where oral administration has a particularly direct anatomical rationale - the compound passes through the GI tract it was originally studied in relation to

But are these claims backed by scientific evidence

Nature 555 (7695), 251255