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Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes

Such a metabolite-protein interaction seeding and stabilizing an assembled oligomeric state is a potent mode of regulation for GS given the nature of a composite active site that is completely inactive in the monomeric state (Figure 2)

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Lee KT, Tsai SM, Wang SN, Lin SK, Wu SH, Chuang SC, et al

glutathione is probably the most important antioxidant you can give your body

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