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At about 40 years of age, practically all patients with Down syndrome exhibit neuropathological changes typical for Alzheimers disease including -amyloid plaques and neurofibrillary tangles (Mann and Esiri 1989)
[CrossRef] [PubMed] 239
& Aparnak, P
Neuron 94 , 1936 (2017)
However, oxygenation of the C4 position by itself appears to be challenging, and simultaneous expression of 3-hydroxybutyrate dehydrogenase 1-like (BDH1L) is required
doi: 10.1080/01616412.2018.1462879 67 MiekusK.MadejaZ
