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The acetyl-CoA enters the Krebs cycle and together with oxaloacetate give rise to citrate, which can be exported to the cytoplasm and engage in NADPH-producing reactions: the transformation of malate to pyruvate catalyzed by malic enzyme (ME1) and the oxidation of isocitrate into -ketoglutarate catalyzed by isocitrate dehydrogenase (IDH1)

[DOI] [PubMed] [Google Scholar] Mayatepek E., Nezu J., Tamai I., Oku A., Katsura M., Shimane M., Tsuji A

Educational initiatives, enhanced physician training, and the availability of accessible, non-judgmental healthcare services may help reduce harm and encourage affected individuals to seek professional support

doi: 10.1016/j.ijdevneu.2015.04.003

37 GlatzJ

[43] Hypothyroidism has been associated with altered ovulatory function, subfertility (the inability to conceive), menstrual irregularities, and higher miscarriage rates