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[84] [85] The 5-reductase inhibitors are contraindicated in pregnant women because of their teratogenicity due to interference with fetal testosterone metabolism, and as a precaution, pregnant women should not handle crushed or broken tablets

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Notably, when a higher cutoff value for elevated serum folate was used in this study (60 nmol/L), the OR associated with high folatelow vitamin B-12 increased in magnitude [2.46 (0.90, 6.71)], although it did not reach statistical significance likely because the sample size of participants with cognitive impairment was only n = 7 (23)