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In pregnant women, vitamin B12 deficiency can cause birth defects and developmental delays

Another strategy involves the use of PARP inhibitor BGP-15, which might protect against CC, to enhance mitochondrial homeostasis 260,261

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A similar line of reasoning involves the kidney in the manifestations of the high-folatelow-vitamin B-12 interaction: depletion of serum vitamin B-12 may also be the result of preferential uptake of folic acid into the renal proximal tubule cells via FR-

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