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Med Toxicol

doi: 10.1016/j.fct.2009.12.011

doi: 10.1016/j.tem.2016.06.010 40 YoshidaTSemprun-PrietoLSukhanovSDelafontaineP

Evolution of phosphofructokinase-gene duplication and creation of new effector sites

One potential application is the utilisation of ZFNs and TALENs to induce heteroplasmy shift in oocytes or embryos containing high levels of the pathogenic mtDNA variant prior to implantation, thereby preventing transmission of LHON to the next generation [46]

This is how you want your fingers to be on the neck of the guitar not flat
