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Studies have shown that HIF-1 can exert protective effects against tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics [27], suggesting complex interactions between HIF-1 signaling, oxidative stress responses, and mitochondrial function
TP53 can also enhance multienzyme activity to facilitate the accumulation of ROS

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R., Barua, A., Uddin, M
