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In the GHK-Cu complex, the Cu (II) ion is coordinated by the nitrogen from the imidazole side chain of the histidine, another nitrogen from the alpha-amino group of glycine, and the deprotonated amide nitrogen of the glycine-histidine peptide bond (Figure 1)

The dose needed depends on how severe the deficiency is and what each person needs

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ALA increases cysteine availability by reducing cystine to cysteine and upregulates the expression of gamma-glutamylcysteine ligase

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