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First human clinical data (2025): Lee et al

651,652 Similarly, CR-boosted NAD + level protects the brain against aging and diseases through attenuating plasma membrane lipid peroxidation, protein carbonyls, nitrotyrosine and oxidative stress

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Degenerative changes, such as disc height loss and anterior osteophyte formation, therefore primarily affect the flexibility in flexion/extension and axial rotation 11,28 , which may explain higher correlation of disc degeneration with the range of motion in these motion planes in the present study