glutathione lipid peroxidation and ferroptosis: The role of GSH and GPx4 Polyunsaturated Fatty Acids Drive Lipid

The model predicted that for 10-hour-long toxicologically relevant doxorubicin (50 M) simulations, the duration of the exposure is more important than concentration with respect to overwhelming glutathione metabolism

[PUBMED Abstract] Asselin BL, Devidas M, Wang C, et al.: Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404)

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References Michalopoulos, G

In support of this hypothesis, GPx-1 overexpression attenuated caspase 8 and caspase 3 activation and diminished release of cytochrome c into the cytosol, concomittant with decreased accumulation of ROS after CD95L activation

Additionally, intravenous infusion of magnesium sulphate remains the drug of choice to prevent and control convulsions caused by eclampsia, significantly reducing maternal mortality related to eclampsia[392]