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Emodin decreases GSH content, xCT and GPX4 expression, increases ROS generation, MDA, and lipid peroxidation, effects reversed by ferroptosis inhibitors and autophagy inhibitors, iron chelator DFO, ferostatin-1, and NCOA4 silencing

To date, several drugs impairing glutamine metabolism have been introduced in clinical trials for various tumor types, including CRC 13

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Patients using oral hormonal contraceptives should discuss additional contraceptive precautions with their prescriber until specific retatrutide data are available

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