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Researchers have summarized and introduced in detail strategies to better limit the off-tumor cytotoxicity of CAR-T cells (52)

A few surviving cells could be expanded into clonal populations

Adaptive immunity, by contrast, is defined by its ability to generate antigen-specific responses and immunological memory, providing robust protection upon re-exposure to previously encountered pathogens (Wang R

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It stabilises cellular membranes, enhances glutathione levels, scavenges reactive oxygen species (ROS), and modulates inflammatory pathways (e.g., NF-B, Nrf2) (de Freitas et al., 2024

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