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[4] Emerging histopathologic markers: Cellular remnants of melanocytes (CRMs) Large CRMs within the nail plate have recently been recognised as a valuable diagnostic marker for distinguishing SUM from benign melanocytic proliferations such as nail matrix nevi (NMN)

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Types of Variables color: Light brown to black (may have color variegation) May have pink/white areas indicating inflammation Inflammation Inflammation is a complex set of responses to infection and injury involving leukocytes as the principal cellular mediators in the bodys defense against pathogenic organisms

After positive results from the Veterans Affairs HDL-C Intervention trial (VA-HIT) trial, showing a 22% reduction in ASCVD with gemfibrozil (1,200 mg/day) in the 1990s [8], major fibrate trials, including the Lower Extremity Arterial Disease Event Reduction (LEADER) [5], Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) [6], and Action to Control Cardiovascular Risk in Diabetes (ACCORD)-Lipid [7] in the 2000s, failed to demonstrate ASCVD prevention with fibrates