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It acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed in multiple tissues including adipose tissue and the liver that plays a role in cellular energy metabolism and fat storage

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These findings are also consistent with the low risk of abuse for tesofensine, as it has been reported to be unlikely to be abused recreationally [60]

If these develop, ultrasound evaluation is necessary

While folate usually gets the spotlight, vitamin B12 is also very much involved in this process