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Free Radical Biol Med (2013) 65:20816

Paracetamol metabolism and related genetic differences

Dai X, Gil GF, Reitsma MB, et al

For neuroprotective mitochondria-targeted drugs with several systemic side effects, such as pitavastatin and pentoxifylline, intranasal drug administration could be a promising option to target the CNS using a lower dose that would minimize systemic exposure, thus decreasing the unwanted adverse systemic effects

doi: 10.1016/j.brainres.2010.12.014 162

In AHH-1 lymphocytes at low doses (4.8 gy or less), gene expression and protein levels of both pro- and anti-ferroptotic biomarkers decreased