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Written by Elizabeth Tito, BSc Genetics, MPH Elizabeth is a science and medical writer with a background in Genetics and Public Health

Following the initial generation, most of the pro-BDNF is then packaged into vesicles in a regulated pathway and undergoes N-terminal cleavage by extracellular proteases, such as plasmin, metalloproteinase gene matrilysin (MMP7) (7,8), tPA/plasmin cascade (8) and extracellular matrix-metalloproteinases (9)