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DSB is metabolized by CYP3A, resulting in the formation of a cis -enedial reactive intermediate (DDE) that selectively and covalently modifies lysine residues on histones, forming pyrroline derivatives, or in cooperation with glutathione (GSH), forming pyrrole derivatives

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1a) [8]

In contrast, Jeng et al

Several possible reasons for the lack of efficacy of antioxidants in clinical trials include (i) insufficient antioxidant levels in the target organ, especially in the nervous system, because an integrated bloodbrain barrier (BBB) is a major obstacle to delivering desired substances, including antioxidants, into the CNS

Collectively, lipid accumulation in NAFLD is supported by enhanced lipogenesis, denoting DNL as a potential therapeutic target