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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

Once activated, dendritic cells migrate into the white pulp to present antigen to naive T cells 24

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287291 Tissue damage effected by these species is augmented by intermittent hypoxia reducing renal expression of antioxidants

USD 39.95 Prices may be subject to local taxes which are calculated during checkout Similar content being viewed by others Abbreviations EGF: epidermal growth factor EGFR: epidermal growth factor receptor HGF: hepatocyte growth factor NSCLC: non-small cell lung cancer SFK: Src family kinase TKI: tyrosine kinase inhibitor TGF-: transforming growth factor- References Bergstrom JD, Westermark B, Heldin NE

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