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Furthermore, a significant reduction in proteasome-mediated degradation of oxidized proteins in brains from MCI and AD subjects was associated with the increase of ox-PTMs such as carbonylation, HNE modification, and neuroprostane conjugation, thereby confirming a role for OS as a contributing factor (354)

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Although it has been demonstrated that Epitalon exerts, among other effects, a direct influence on melatonin synthesis, alters the mRNA levels of interleukin-2, modulates the mitogenic activity of murine thymocytes, and enhances the activity of various enzymes, including AChE, BuChE, and telomerase, it remains uncertain whether these are the sole mechanisms of action of this compound

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