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Multiple treatment modalities for hyperpigmentation that shift eumelanin to pheomelanin synthesis exist

Wagenknecht LE, Scherzinger AL, Stamm ER, Hanley AJ, Norris JM, Chen YD, Bryer-Ash M, Haffner SM, Rotter JI (2009) Correlates and heritability of nonalcoholic fatty liver disease in a minority cohort

To stabilize themselves, they react with nearby molecules, damaging DNA, proteins, cell membranes and lipids in the process

Additionally, given that treatment is most effective if given early in the disease course or before patients become overtly symptomatic (Dzieyc et al., 2014), there is an increasing use of molecular diagnostics in first degree relatives of patients with WD to identify known homozygous or compound heterozygous mutations in such individuals (Ala et al., 2007