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strain C190: cloning and construction of gene-specific primers

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[DOI] [PMC free article] [PubMed] [Google Scholar] Liman TG, Endres M

In Shi et al, Lactobacillus rhamnosus GG (LGG) was shown to modulate T-bet expression and Th1 differentiation via two metabolite-mediated pathways regulation of T-bet, EPS engage the TLR2/MyD88 dendritic cell pathway with subsequent production of IL-12 and resultant STAT4 phosphorylation that directly amplifies T-bet, and SCFAs, such as butyrate, repress histone deacetylases (HDACs), enhancing Tbx21 promoter acetylation to increase T-bet expression

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IV delivery replenishes these directly, bypassing the GI absorption limits that slow oral repletion post-exertion