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The reactive chemical 4-HNE is known to bind and form adducts to macromolecules including DNA [80], and cell culture studies demonstrate that Nrf2 and glutathione are needed to protect cells from 4-HNE and lipid peroxidation toxicity [81]

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ATP7B-deficient hepatocytes reveal the importance of protein misfolding induced at low copper concentration

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Liu H, Forouhar F, Seibt T, Saneto R, Wigby K, Friedman J, et al

The peak of the rate of -amyloid deposition reaches between 35 and 45 years of age