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A recent systematic review and meta-analysis of 21 randomized, placebo-controlled trials examining the effect of B-vitamin supplementation found the supplementation decreased homocysteine concentrations and improved measures global cognitive function but had no effect on individual measures of executive function, information processing speed, or episodic memory (89)

One 2021 review study in the Journal of Personalized Medicine found that, in individuals with autism spectrum and CFD, side effects of leucovorin were generally mild, but in some cases included aggression, agitation, headaches, insomnia and increased tantrums

10.1155/2015/512618 89 MaieseK

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