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Severe Hypokalemia: A Critical Drop in Potassium Levels One of the most serious complications of B12 replacement therapy in severe megaloblastic anemia (a type of anemia where blood cells are abnormally large) is the development of severe hypokalemia (dangerously low potassium levels in the blood)

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[DOI] [PubMed] [Google Scholar] 238.Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschp MH

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In turn, RhoA activates Rho associated kinase (ROCK), which leads to increased Ser 19 -MLC and thereby, vasoconstriction [19,20]

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