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Its theorized that interactions with dopaminergic and serotonergic pathways have also encouraged exploration into its possible impacts on neuro-gastrointestinal circuits

They should be used with caution in women who have allergies to latex or spermicides, vaginal anatomy abnormalities, a history of Toxic Shock Syndrome, or recurrent urinary tract infections

Pseudoinvasion of blood vessels may be present

Astrocyte-Derived Proinflammatory Cytokines Induce Hypomyelination in the Periventricular White Matter in the Hypoxic Neonatal Brain
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Richard Blumenthal, in response to The Connecticut Mirror and ProPublicas analysis
