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Description
Excessive NAM depletion directly reduces the substrate supply for NAD+ synthesis, leading to decreased intracellular NAD+ levels
The proposed chain of effects looks like this: NNMT inhibited nicotinamide is no longer inactivated by methylation and becomes available for conversion to NAD+
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70 HP 150 5-AMINO-1MQ Small-molecule NNMT inhibitor body-composition research ALIASES 5A1MQ, 5-amino-1-methylquinolinium iodide, NNMT inhibitor CLASS Small-molecule NNMT inhibitor (not a peptide) FORMULA C10H11IN2 HALF-LIFE Short plasma half-life (oral bioavailable) ROUTES Oral (in animal studies) Subcutaneous (research) MECHANISM OF ACTION 5-Amino-1-methylquinolinium iodide
Clinical trials did not include pregnant or breastfeeding women, children, elderly individuals over 65, or those with active malignancy or severe organ dysfunction
Abdominal bloating decreases (partly from visceral fat reduction, partly from reduced inflammation in adipose tissue)
