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The Immunogenicity Argument The FDAs primary objection to DSIP is the risk of immunogenicity

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Post-hoc HPLC analysis of retained samples confirmed greater than 70% degradation

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Avoid deeply discounted peptides that may be near expiration

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Backbone-cyclized analogues with fewer disulfide bonds have been reported, but these often lack structural integrity and are likely to show compromised activity

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Methods for preparation of niosomes: a focus on thin-film hydration method

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