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Description
This leads to a number of secondary motor and non-motor symptoms 9,11 such as neuropsychiatric disorders (anxiety and depression), autonomic dysfunction (constipation), sleep abnormalities (insomnia), olfaction and visual disorders, and cognitive decline including dementia 12,13

preprint: Desrochers et al , 2018

Initially, gingivitis develops which is characterized by redness, swelling, and bleeding of the gingiva

Stereotactic surgery and LPS treatment Mice at 56 weeks of age were stereotactically injected with 500 nL of AAV (2.0 10 10 GC/L) at the rate of 100200 nL/min into the medial prefrontal cortex (mPFC) bilaterally using a NanoFil syringe (WPI) with a 35G beveled needle

CoQ10: A coenzyme essential for energy production

They are powerful, but that blunt approach can also slow healing and carry side effects over time
