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doi: 10.3389/fvets.2025.1554771 Received 02 January 2025 Accepted 27 February 2025 Published 02 April 2025 Volume 12 - 2025 Edited by Eliana Pintus, Czech University of Life Sciences Prague, Czechia Reviewed by Alfredo Medrano, National Autonomous University of Mexico, Mexico Alok Kumar, Bihar Animal Sciences University, India Updates Copyright 2025 Bodu, Hitit, Greenwood, Murray and Memili

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It was proven that patients with early carnitine treatment and without frequent metabolic decompensations were less vulnerable to the development of pathological, neurological, and neuropsychological attributes, including ASD, in research concerning eight propionic acidosis patients with autistic symptoms (e.g., repeated movements or hand fluttering, stereotypic behavior, disturbances in social interactions, difficulty in communication with other people), who were treated with L-at 50 mg/kg/daily, biotin at 10 mg/day, and a low-protein diet [131]

In vitamin C supplementation studies, as well as those for other nutrients, consideration of dose-concentration relationships is critical to good study design (Levine et al 1999a) (Padayatty & Levine, 2009) (Morris & Tangney, 2011) (Lykkesfeldt & Poulsen, 2010)

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Martin K, Andreas S, Jrg S, Shearer MJ