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An adverse outcome pathway for decreased lung function focusing on mechanisms of impaired mucociliary clearance following inhalation exposure

Among nanoparticles of identical volume but of varying shapes and densities, pollen-like particles have shown superior performance for inhalation, owing in part to their inherent porosity, which improves aerosolization, flowability and deposition, all suited for inhaled drug delivery 132

Some peptides are FDA-approved for specific indications (e.g., Emdogain for periodontal regeneration)

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The rate of metastasis has been shown to be higher in HER2 + breast cancer and TNBC compared to luminal subtypes (ER + and PR+) of breast tumpr

Its use is limited to one year due to its association with increased incidence of cardiovascular and cerebrovascular events (eg, heart attack and stroke), as well as atypical femur fractures and osteonecrosis of the jaw