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Non-canonical amino acid labeling in proteomics and biotechnology

However, highly cationic CPPs can cause cytotoxicity 46 and may escape from vesicles to the cytosol during the transcytosis process due to the electrostatic interaction of the peptide sequence with the negatively charged membrane where they are trapped in, which may facilitate trapping of the peptide in the brain endothelium

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Qi SS, Shao ML, Sun Z, Chen SM, Hu YJ, Wang HT, Wei TK, Li XS, Zheng HX

2016), nephrotoxicity and hepatotoxicity induced by sodium arsenite (Turk et al