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Individuals with DM and non-fasting TG levels between 1.3 and 2.3 mmol/L (115 and 200 mg/dL) or between 1-2 mmol/L (89 and 175 mg/dL) may benefit from an OFTT, whereas those with fasting TG levels below 1 mmol/L (89 mg/dL) may experience exaggerated postprandial hypertriglyceridemia, especially those with diabetic nephropathy (70)

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GLS1 functions as the primary isoform under most conditions, while GLS2 can be induced under specific contexts such as p53 activation, partially compensating for GLS1 activity and thereby adding complexity to its therapeutic targeting [183]

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doi: 10.1016/j.cmet.2006.01.004