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While the study volunteers were older adults, who may have a specific vulnerability to lower levels of B12, co-first author Alexandra Beaudry-Richard, MSc, said that these lower levels could impact cognition to a greater extent than what we previously thought, and may affect a much larger proportion of the population than we realize. Beaudry-Richard is currently completing her doctorate in research and medicine at the UCSF Department of Neurology and the Department of Microbiology and Immunology at the University of Ottawa

At the molecular level, chronic AOD9604 administration upregulates 3 adrenergic receptors in fat tissue, reversing obesityrelated suppression of these fatburning receptors [9]

Taking both together makes sense for most people, though folate status should be adequate before starting high-dose b12 to avoid masking folate deficiency

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Increase of Fat Oxidation and Weight Loss in Obese Mice Caused by a Modified C-Terminal Fragment of Growth Hormone (AOD-9604)