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Ehlers-Danlos Hypermobility Syndrome: Mast cells and high histamine in the joints are a possible underlying cause of hypermobility syndrome

supervision, G.P

[Abstract]2026 Jan 21;21(1):e0341445

Previous attempts of targeting signaling cascades in neurofibroma microenvironment through imatinib mesylate administration, a dual SCF/cKIT inhibitor, have shown modest response rates limited only to small tumors [53] ( Cabozantinib, an inhibitor of multiple tyrosine kinases among which c-Kit, vascular endothelial growth factor (VEGF) receptor (VEGFR)2, MET, RET, FMS-related RTK 3 (FLT3) and TAM family receptors (tyrosine kinases AXL, TYRO3 and MERTK) is now under study in a phase II trial against progressive or symptomatic, inoperable PN ( as it has shown promising results in Nf1-mutant mice [54]

Journal of ocular pharmacology and therapeutics: the official journal of the Association for Ocular Pharmacology and Therapeutics.Apr 1999;15(2):143-152