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They include: Tackling Free Radicals and Oxidative Stress

Histamine and Depression: The Overlooked Connection The relationship between histamine and depression is often missed because histamine-driven depression does not resemble classic low-energy depression

Through in-depth in vivo isotope tracing, five labeled metabolites were detected with this characteristic including NAAG, N-acetyl-glutamine, glutamylalanine, glutamylglutamate, and glutamylglutamine

Tzadok R, Ablin JN

Accordingly, several inhibitors of kinases, enzymes involved in these pathways, have been developed and some are in clinical development, but concerns about the specificity and/or safety of this approach have been raised and its efficacy is still questionable

Viswanath, B., Rajesh, B., Janardhan, A., Kumar, A
