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3.4.1 Protective effects of metformin on cardiovascular disease risk in patients with polycystic ovary syndrome Epidemiological research suggests that individuals with PCOS exhibit a greater prevalence of hypertension compared to those without PCOS, particularly among females of reproductive age, and their cardiovascular risk is notably elevated irrespective of their BMI

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Cagrilintide shows dual selectivity for AMY1 and AMY3 receptors with reduced calcitonin-receptor activation relative to the parent endogenous amylin peptide, a profile achieved through targeted residue substitutions that the 2021 Kruse development paper documents in detail (PMID 34288673)