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Ten minutes of forebrain ischemia in adult rats led to a significantly decreased number of intact neurons in hippocampal tissue, decreased concentrations of glutathione and ATP, and increased total nitrate/nitrite and thiobarbituric acid-reactive substances which accumulate in conditions of oxidative stress [133]

Lee, H.P

| doi:10.1007/s10545-007-0666-z Constantin-Teodosiu D, Carlin JI, Cederblad G, Harris RC, Hultman E: Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise (1991) Acta Physiol Scand | doi:10.1111/j.1748-1716.1991.tb09247.x Diamanti K, Cavalli M, Pan G, et al.: Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes

These findings led Lonza to explore whether L-carnitine tartrate could modulate the expression levels of ACE2 in cultured Calu-3 cells, thereby moderating SARS-CoV-2 infectivity 5