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They undergo bioreductive activation in the presence of reductants such as ascorbic acid and glutathione but afford greater stability in the bloodstream allowing more drugs to reach their biological targets [20,24,28,29,30,31,32]
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Subsequently, 3-hydroxy-methylglutaryl-CoA lyase (HMGCL) cleaves HMG-CoA in an irreversible reaction into acetyl-CoA and the first ketone body, AcAc
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Part 2, chapter, 10, pp 85-91, in Scientific publication no
