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The oxidative stress and the polyol pathway were significantly higher in insulin dependent diabetes mellitus (IDDM) patients and diabetic cataract than controls and non-insulin dependent diabetes mellitus (NIDDM) patients ( Tables 2 and 3 and Figure 1A and 1B ) which may be attributed to the excessive ROS generation in IDDM patients

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

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JCI Insight 5 , e135923 (2020)

Adult Neurobehavioral Alterations in Male and Female Mice Following Developmental Exposure to Paracetamol (Acetaminophen): Characterization of a Critical Period
