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In the brain, the effects are different but equally important

In the controls, the lesion area was still large, along with edema, necrosis of muscle fibers, and acute inflammation with foci of abscessation

The underlying pathogenesis reflects a complex interplay between viral activity and the host immune response, driving progressive liver injury that can ultimately lead to serious complications such as cirrhosis and hepatocellular carcinoma (495)

[DOI] [PMC free article] [PubMed] 181.Uddin M.S., Al Mamun A., Kabir M.T., Jakaria M., Mathew B., Barreto G.E., Ashraf G.M

However, in the early phase after the application of targeted therapy, especially the first 2448 h, multiple protective signaling pathways would be rapidly activated to mitigate the pro-apoptotic effect of targeted agent, which is defined as adaptive resistance