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doi: 10.1001/jama.2016.17441 25 NegroMMarzulloNCasoFCalanni PirelliLDAntonaG

While these drugs can reduce inflammation, their clinical utility in acute MI is significantly hampered by substantial side effects, such as increased cardiovascular risk (particularly with certain NSAIDs) and systemic immunosuppression (with corticosteroids) (Tardif et al., 2019

Dietary folic acid addition reduces abdominal fat deposition mediated by alterations in gut microbiota and SCFA production in broilers

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103,104,105 These toxic side effects are caused, at least in part, by the synergistic activity of glutaminase in ASNase

Recently, it was also found that valsartan, an angiotensin II inhibitor, could inhibit BCKDH-BCKDK interaction, decrease BCKDH phosphorylation, and decrease plasma BCAA concentration to increase BCKDH enzyme activity