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therefore, levels of glutathione (GSH), the key anti-oxidant guardian in all tissues, could be critical in extinguishing the exacerbated inflammation that triggers organ failure in COVID-19

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

The human genome harbours twenty-five selenoprotein genes, of which eight GPx paralogues have been identified, namely GPx1 (locus 3p21.3), GPx2 (locus 14q24.1), GPx3 (locus 5q23), GPx4 (locus 19p13.3), GPx5 (locus 6p22.1), GPx6 (locus 6p22.1), GPx7 (locus 1p32) and GPx8 (locus 5q11.2) (Reference Zmorzyski, widerska-Koacz and Koczkodaj125)

Clinically, this manifests as peripheral neuropathy, characterized by numbness, painful tingling, burning sensations in the extremities, and eventual loss of motor function