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Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice

Grube, S., Freitag, D., Kalff, R., Ewald, C

Decades of Research

However, adverse effects may limit the treatment potential, e.g., glitazones are associated with phenotypical weight gain [136] and obeticholic acid induced pruritus and elevated LDL-C [137], the latter a potential concern in patients already at risk for cardiovascular disease

[DOI] [PubMed] [Google Scholar] 154.Kim C.Y., Shaban S.M., Cho S.Y., Kim D.H

Moreover, mitochondria are involved in cell death signaling and contribute to oxidative stress regulation