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467 Additionally, enzymatic or cellular reactions occurring within biological systems present advantages such as mild conditions and high selectivity

Since it is difficult to modify intrinsic GSH reactivity in the presence of cellular GST, warheads with reduced reactivity are preferred to minimize the non-specific covalent binding burden on proteins, which correlates with the in-vitro reaction rate of the drug and GSH [105,106]

To verify the binding capability of p53 TAD PEP to the FOXO4 FHD, we performed FPA

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Fernandez JM, Hendricks AJ, Thompson AM, et al